Epithalon

Epithalon, also known as Epitalon or AEDG peptide, is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from naturally occurring Epithalamin from the pineal gland. Within peptide science, Epithalon is studied for its role in telomere-related pathway dynamics, transcription regulation and pineal signaling models. In preclinical research contexts, the peptide is associated with enzymatic modulation and chromatin dynamics within experimental systems (Khavinson V.Kh. et al., 2003).

History of Epithalon

Epithalon was developed in the 1980s at the St. Petersburg Institute for Bio-regulation and Gerontology as a synthetic analogue of Epithalamin, a natural peptide fraction from pineal tissues. Early studies characterized the interaction with pineal regulation mechanisms and circadian signaling pathways. Later studies extended the investigation to telomere-related enzymatic models and chromatin dynamics, making Epithalon a widely studied peptide within molecular gerontology and transcriptional research (Khavinson V.Kh., Bondarev I.E., Butyugov A.A., 2003).

Epithalon structure and molecular data

Peptide Name: Epithalon (Epitalon, AEDG peptide) Peptide Type: Synthetic tetrapeptide Sequence: Ala-Glu-Asp-Gly

CAS#: 307297-39-8 Molecular Formula: C14H22N4O9 Molecular Weight: 390.35 g/mol PubChem ID: 219042

The tetrapeptide structure is designed for interaction with telomerase-related enzymes and chromatin dynamics, studied within cellular-biological and gerontological research contexts.

Epithalon Research Findings

Epithalon has been investigated in models of cellular senescence, transcription regulation and enzymatic modulation. Studies report activity related to:

Interaction with telomerase and telomere elongation in somatic cell models

Modulation of pineal signaling and circadian pathways

Enzymatic modulation within chromatin remodeling

Influence on senescence biomarkers in preclinical models

Major Research Areas of Epithalon

Chromatin & Telomere Focus on telomere dynamics, enzymatic modulation and transcription regulation.

Endocrine Investigating pineal signaling, circadian pathways, and melatonin-related dynamics.

Cellular Study of senescence models, molecular remodeling and pathway characterization.

Scientific Relevance of Epithalon

Epithalon is considered a relevant research molecule for studies on cellular senescence, telomerase-related pathways, and pineal signaling. By interacting with telomere-related enzymes, it provides a tool for research into chromatin dynamics, circadian biology, and molecular gerontology in controlled in-vitro research environments.

References

Khavinson V.Kh., Bondarev I.E., Butyugov A.A. (2003). Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bulletin of Experimental Biology and Medicine, 135(6), 590–592. Anisimov V.N. et al. (2003). Effect of Epitalon on biomarkers of aging, life span, and spontaneous tumor incidence in female CBA mice. Biogerontology, 4(4), 193–202. Korkushko O.V. et al. (2007). Peptide geroprotector Epitalamin: a 20-year follow-up. Advances in Gerontology, 20(2), 74–84.