Cagrilintide

Cagrilintide, also known as AM833 or NN0174-0833, is a synthetic, acylated peptide analogue of amyline (37 amino acids) developed as a long-acting agonist of amylin receptors (AMYR) and calcitonin receptors (CTR). Within peptide science, Cagrilintide is studied for its interaction with AMYR/CTR receptor complexes, downstream signaling cascades, and long-term receptor-binding kinetics in preclinical research models (Lau D.C.W. et al., 2021).

History of Cagrilintide

Cagrilintide evolved from research into long-active amyline analogues. Natural amyline has a short plasma half-life, which made preclinical characterization difficult. Through amino acid substitutions and lipid acylation – similar to the optimization strategy applied in GLP-1 analogues – Cagrilintide has been designed as a more stable molecule with extended receptor interaction duration. This strategy represents an extension of peptide engineering within endocrine-focused research (Kruse T. et al., 2021).

Cagrilintide Structure and Molecular Data

Peptide Name: Cagrilintide (AM833, NN0174-0833) Peptide Type: Synthetic Acylated Amyline Analogue (37 amino acids)

CAS#: 1415456-99-3 Molecular Formula: C194H312N54O59S2 Molecular Weight: 4409.01 g/mol

The acylated peptide structure is designed for prolonged receptor interaction duration with amylin (AMYR) and calcitonin (CTR) receptor complexes, studied within endocrine and metabolic research contexts.

Cagrilintide Research Findings

Cagrilintide has been investigated in preclinical and in-vitro models targeting amylin and calcitonin receptor interaction, satiêtion-related signaling pathways, and long-term plasma stability. Studies describe the interaction with AMYR/CTR complexes and receptor-mediated pathway dynamics in metabolic and endocrine research contexts.

Major Research Areas of Cagrilintide

Endocrine

Focus on AMYR/CTR receptor interaction, amylin pathway dynamics, and receptor-mediated signaling.

Metabolic

Investigation of satiêtion signaling models, energy homeostasis pathways, and postprandial glucose dynamics.

Peptide Engineering

Study of lipid acylation, plasma stability, and long-term receptor binding kinetics.

Scientific Relevance of Cagrilintide

Cagrilintide is considered a relevant research molecule for studies of endocrine and metabolic signaling models. Through long-term interaction with amylin and calcitonin receptor complexes, it provides a valuable platform for research into receptor-mediated pathways and peptide engineering strategies in controlled preclinical laboratory settings.

References

Lau D.C.W. et al. (2021). Once-weekly cagrilintide for weight management. The Lancet, 398(10317), 2160–2172. Kruse T. et al. (2021). Development of cagrilintide, a long-acting amylin analogue. J Med Chem, 64(15), 11183–11194. Andreassen K.V. et al. (2021). AM833 is a novel agonist of calcitonin family GPCRs. JPET, 378(1), 26–34.