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IGF 1 LR3
€ 66,95
Don't forget the reconstitution water
Required for dissolving freeze-dried peptides.
All products are intended for laboratory research only and are not suitable for human or animal consumption. By purchasing, the buyer agrees to use these products in accordance with all applicable laws.
This substance has not been evaluated or approved by the European (EMA), American (FDA) or Dutch (MEB/IGJ) medicines authorities for any human or veterinary use. No medical, therapeutic, diagnostic or preventive use is claimed or implied.
IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a synthetic analogue of IGF-1, designed for increased stability and prolonged activity within experimental research environments. It is widely studied within molecular, cellular, and biochemical research due to its interaction with growth signaling pathways and receptor-mediated processes.
Compared to natural IGF-1, IGF-1 LR3 has structural modifications that reduce binding to IGF-binding proteins (IGFBPs), increasing bioavailability in laboratory models. Because of this, it is often used in studies of cellular signaling, pathway activation, and molecular regulation.
History of IGF-1 LR3
IGF-1 LR3 was developed to overcome the limitations of natural IGF-1, particularly its short half-life and strong binding to IGF-binding proteins. Structural modifications created a compound with longer activity and improved receptor interaction.
Early studies focused on cellular proliferation and signaling pathways, while later studies expanded to metabolic regulation, tissue models, and dynamics of molecular pathways.
Today, IGF-1 LR3 remains an important research compound in studies of growth factor signaling and cellular response mechanisms.
IGF-1 LR3 Structure and Molecular Data
Peptide Name: IGF-1 LR3 (Long Arg3 IGF-1)
Peptide Type: Growth Factor Analog
Sequence modification: Arg substitution at position 3 + extended N-terminal sequence
Molecular Formula: C400H625N111O115S7
Molecular Weight: ~9200 g/mol
The structural modifications allow IGF-1 LR3 to interact more efficiently with IGF-1 receptors (IGF-1R), making it relevant for receptor binding studies and signaling pathway research.
IGF-1 LR3 Study Findings
IGF-1 LR3 has been extensively investigated in cellular and molecular models with a focus on growth factor signaling and pathway activation.
Research shows activity related to:
• IGF-1 receptor (IGF-1R) interaction and signaling
• Cellular proliferation and differentiation processes
• Protein synthesis signaling and molecular regulation
• Metabolic and biochemical pathway dynamics
Major Research Areas of IGF-1 LR3
Cellular Research
Focus on cell signaling, proliferation and response mechanisms.
Molecular research
Study of receptor binding, pathway activation and signal modulation.
Metabolic Research
Analysis of interactions between growth factors and metabolic pathways.
Systemic Research
Research into coordinated biological processes within complex systems.
Scientific Relevance of IGF-1 LR3
IGF-1 LR3 is considered a potent growth factor analogue used in experimental research on cellular signaling, receptor interaction and pathway activation.
Due to its reduced binding to IGF-binding proteins and its prolonged activity profile, it is particularly suitable for models that require long-term signaling and increased receptor activity.
Due to its central role in growth factor pathways, IGF-1 LR3 remains relevant within molecular biology, peptide research and biochemical studies.
References
Le Roith D. et al. (2001). Insulin-like growth factors and their receptors.
Baker J. et al. (1993). IGF-1 receptor signaling pathways.
Jones JI. et al. (1995). Role of IGF-binding proteins in IGF regulation.
Our Process
Frequently asked questions
Each batch is independently tested by third-party laboratories using HPLC and mass spectrometry. You can view the Certificate of Analysis (COA) of your specific batch on our lab results page.
Orders placed before 15:00 will be shipped the same day from our EU warehouse. Delivery typically takes 1–3 business days, depending on your location within Europe.